Rho/Rac proteins constitute a subgroup of the Ras superfamily of GTP hydrolases. Although originally implicated in the control of cytoskeletal events, it is currently known that these GTPases coordinate diverse cellular functions, including cell polarity, vesicular trafficking, the cell cycle and transcriptomal dynamics. In this review, we will provide an overview on the recent advances in this field regarding the mechanism of regulation and signaling, and the roles in vivo of this important GTPase family. BioEssays 29:356–370, 2007. © 2007 Wiley (...) Periodicals, Inc. (shrink)

The coronavirus disease 2019 pandemic is altering dynamics in academia, and people juggling remote work and domestic demands – including childcare – have felt impacts on their productivity. Female authors have faced a decrease in paper submission rates since the beginning of the pandemic period. The reasons for this decline in women’s productivity need to be further investigated. Here, we analyzed the influence of gender, parenthood and race on academic productivity during the pandemic period based on a survey answered by (...) 3,345 Brazilian academics from various knowledge areas and research institutions. Productivity was assessed by the ability to submit papers as planned and to meet deadlines during the initial period of social isolation in Brazil. The findings revealed that male academics – especially those without children – are the least affected group, whereas Black women and mothers are the most impacted groups. These impacts are likely a consequence of the well-known unequal division of domestic labor between men and women, which has been exacerbated during the pandemic. Additionally, our results highlight that racism strongly persists in academia, especially against Black women. The pandemic will have long-term effects on the career progression of the most affected groups. The results presented here are crucial for the development of actions and policies that aim to avoid further deepening the gender gap in academia. (shrink)

Na linha do recente debate sobre a cidadania surgem novamente algumas questões fundamentais que se nos colocam a propósito do conflito entre liberdade e igualdade. O presente artigo pretende reflectir sobre os problemas de igualdade económica, social e política e as exigências de justiça e de liberdade que os acompanham, tomando como centro as capacidades e as necessidades de cada um. Nesse sentido, a autora recorre sobretudo às aportações de Martha C. Nussbaum e de Iris M. Young. /// Following the (...) thread of the recent debate on citizenship, there are some some fundamental questions that emerge regarding the conflict between liberty and equality. This paper constitutes a reflection about the problems of social, political and economic equality and the demands of justice and liberty that they involve. The analysis is centered on the capabilities and the needs of each person. In order to do this, the author refers in particular the conceptions developed by Martha C. Nussbaum and Iris M. Young. (shrink)

In this paper I discuss the concept of the right to the city in articulation with the concept of urban play and more specifically, the diverse body of research related with playable and playful cities. Following a brief review of these two concepts and related studies, I critically discuss the possibilities of articulating Lefebvre's radical concept of the right to the city to contemporary interventions on urban and digital play.

This collection addresses a post-WWII shift in the hierarchy of scientific explanations, where the highest goal moves from reductionism towards some ...

‘Historical thinking’ has a central role in the theory and practice of history education. At a minimum, history educators must work with a model of historical thinking if they are to formulate potential progression in students’ advance through a school history curriculum, test that progression empirically, and shape instructional experiences in order to maximize that progression. Where do they look, and where should they look, in order to construct such models? Over the past several decades, three major strands have developed, (...) one based in the empirically minded and instruction-oriented British Schools Council History Project, a second through the more philosophically oriented German field of history didactics and historical consciousness, and a third in the US. All three had roots in the historiography and philosophy of their own national traditions. Canadian history educators have been working with a pragmatic hybrid defined around six ‘historical thinking concepts.’ While this model has both been highly influential in the reform of Canadian history curricula and prompted adaptations elsewhere, there has been only minimal theoretical discussion exploring the relationship of these concepts to each other or to the three traditions which helped to shape them. This article is a contribution towards filling that gap. (shrink)

Metastasis is one of the clinical parameters that has a strong negative influence on the prognosis of cancer patients. In recent years, significant advances have furthered our understanding of this process at the molecular and biological levels. This paper will discuss recent discoveries relating to the earliest, intra‐tumoral stages of metastasis in cancer cells, specifically focusing on: (i) the development of metastatic traits during primary tumorigenesis; (ii) intrinsic and extrinsic cancer cell programs associated with malignant traits; (iii) the intra‐tumoral migration (...) patterns of cancer cells and the dynamic roles played by the Rho/Rac GTPases and epithelial‐mesenchymal transitions in this process; and (iv) the genetic strategies used by metastatic cancer cells to promote intra‐tumoral cell migration and their subsequent escape to peripheral tissues. Finally, the therapeutic and diagnostic relevance of this information will be discussed, as well as potential future developments. (shrink)

Experiments with cell lines have unveiled the implication of the Rho/Rac family of GTPases in cytoskeletal organization, mitogenesis, and cell migration. However, there have not been adequate animal models to investigate the role of these proteins in more physiological settings. This scenario has changed recently in the case of the T‐cell lineage after the generation of animal models for Rho/Rac family members, their regulators, and effectors. These studies have revealed the implication of these GTPases on multiple regulatory layers of T‐cells, (...) including the coordination of cytoskeletal change, activation of kinase cascades, stimulation of calcium fluxes, and the induction of gene expression. These pathways affect the transition of different T‐cell maturation stages, the positive/negative selection of thymocytes, T‐cell responses to antigens, and the homeostasis of peripheral T‐lymphocytes. Moreover, these animals have revealed interesting cross‐talks between Rho/Rac pathways and other signal transduction routes that participate in lymphocyte responses. BioEssays 24:602–612, 2002. © 2002 Wiley Periodicals, Inc. (shrink)

For the theorists of crisis, the revolutionary state comes into existence through violence, and due to its inability to provide an authoritative katechon (restrainer) against internal and external violence, it perpetuates violence until it self-destructs. Writing during extreme economic depression and growing social and political violence, the crisis theorists––Joseph de Maistre, Juan Donoso Cortés, and Carl Schmitt––each sought to blame the chaos of their time upon the Janus-faced postrevolutionary ideals of liberalism and socialism by urging a return to pre-revolutionary moral (...) and religious values. They are united by three counterrevolutionary principles, all of which are purported to remedy revolutionary violence: traditional constitutional fidelity, the philosophy of the decision, and opposition to bourgeois liberalism. This essay is followed by the first complete English translation and publication of Donoso’s letter of October 24, 1851, which contains Donoso’s only reference to the “discussing class,” a political entity later popularized by Schmitt in his 1922 work Political Theology. (shrink)

In aiming to frame plagiarism as an academic literacy issue, this paper focuses on the strategies used by firsts years Portuguese university students, when writing from sources, along with the relationship between these strategies and the way students view themselves as readers, writers and users of sources. The study was based on 44 short summary essays written by students as well as their responses to a questionnaire and checklist on citation rules. The evaluation of the essays revealed that students often (...) use copying and patchwriting. In addition, we found that much of the time students changed the meaning of the content expressed in the source. In relation to the way students evaluated themselves, generally their view was they used appropriate strategies. The study did not reveal a relationship between perceptions of using appropriate strategies and the use of those same strategies. Nonetheless, we found an association between performance and perceptions of using copying. Perceived use of a ‘think-then-do’ strategy was also related to changing the meaning when writing from sources. Concerning school achievement, stronger students evaluated themselves as using more appropriate strategies, and those who had not previously failed school year also displayed a better knowledge of citation rules. However, we failed to find any relationship between school achievement and the use of strategies for writing from sources. The main findings of the current research point to the existence of issues concerning how to address academic literacy, findings that go beyond plagiarism and, consequently, indicate the need for pedagogical responses. (shrink)

Some theories of goodness are descriptively rich: they have much to say about what makes things good. Neo-Aristotelian accounts, for instance, detail the various features that make a human being, a dog, a bee good relative to facts about those forms of life. Famously, such theories of relative goodness tend to be comparatively poor: they have little or nothing to say about what makes one kind of being better than another kind. Other theories of goodness—those that take there to be (...) absolute goodness—are comparatively rich: they offer grounds for judging some types of things better than others because they have more absolute goodness. Moorean accounts, for example, can tell us that humans and human experiences are superior to bees and blades of grass. But such theories tend to be descriptively poor: they struggle to tell us in virtue of what this is so. In this essay we motivate and flesh out a view that splits the difference between accounts of goodness as relative and accounts of goodness as absolute. Such a view holds promise only if the mechanics of this kind of metaphysics of goodness can be worked out. Here we present a view on which the paradigm for absolute goodness is God and the paradigm for each kind of relative goodness is a divine idea. (shrink)

This paper analyses the suitability of Effective Altruism as an ethical frame for the practices of Education for Global Citizenship in the University. According to Effective Altruism, altruistic and solidary practices should be based not only on emotional decisions, but also on a rational analysis to achieve the greatest possible impact for the benefit of third parties. Simultaneously, Universities promote Education for Global Citizenship that includes the development of competencies for the application of ethical principles focused on the improvement of (...) the world as defined in the United Nations 2030 Agenda for Sustainable Development. But the breadth of development problems demands decision criteria to select those causes that can have a greater and better impact. Therefore, Effective Altruism enumerates a reasoned repertoire of decision criteria that could facilitate the application of ethical principles among university global citizenship. (shrink)

Neste artigo, desenvolveremos algumas considerações gerais, referentes a noção de biopolítica e biopoder de Michel Foucault relacionadas com a teoria da Necropolítica, enquanto política de morte e o exercício do necropoder, proposta pelo pensador camaronês Achille Mbembe e como essa se relaciona ao fenômeno de pandemia da Covid-19. Pretendemos assim problematizar, à luz dos aportes teóricos tanto da reflexão perpetrada por Michel Foucault, a partir do conceito de Biopolítica, quanto da noção de Necropolítica proposta por Mbembe, as questões políticas e (...) éticas presentes no contexto da eclosão desta pandemia, objetivando criticar e analisar nossa atualidade política dominada por uma racionalidade neoliberal hegemônica e intensamente destrutiva, presente na forma da gestão das condições de saúde e da vida da população por parte dos Estados. (shrink)

Our abstract begins with the question: what means the sentence - the life is a capital? Michel Foucault makes the question when he signalizes that the bio-power is connected to the capitalism. In this case, the question is to understand how the increase and the confiscate of wealth suppose the power’s development that captures the life strength to make them participe to the wealth creation process. What other fundamental question could be emphasized? The contemporaneous capitalism is strictly connected to method (...) of subjetictivity production. In Nascimento da biopolítica Foucault shows how the capitalism appeals to the people to construct their lives like enterprises. It refers to homo oeconomicus like a suject that considers himself as a valuable capital. We realize the human capital is managed like lives markets, through the neoliberal biogovernamentality, regulating the sujects conducts by a place of truth, the market . We propose the constitution of a new subjectivity: the homo dispensatio. Tracing the relation between the life management as a capital and the constitution of this subjectivity, we could signalize what this situation can provide from the ethical and political viewpoint. (shrink)

Aunque, para Deleuze, un empirista es capaz de seguir los desequilibrios presentes en el funcionamiento práctico de las sociedades, de guiarse en ese plano cuyas relaciones no están predeterminadas, es necesario que además pueda servirse de algún medio de orientación en ese plano móvil, representado aquí por el cuerpo de una sociedad. Deleuze extrae del cuerpo social el peso y la inmovilidad de la estructura, incapaz de pensar la lógica de esos desequilibrios, para llenarlo de líneas con cualidades desiguales, capaces (...) de movimientos diferentes. Unas son más duras, delimitando territorios aparentemente estables, otras más flexibles, produciendo siempre zonas de inestabilidad en esos territorios, siendo a veces reintegradas al equilibrio anterior, a veces apuntando a un nuevo equilibrio, o simplemente a la muerte del antiguo. Este artículo trata de explorar esa lógica de las lineas con la cual Deleuze construye otra imagen de las sociedades. (shrink)